Remus 0.1% Ointment 10gm

✔️ Uses of Remus 0.1% Ointment 10gm

Moderate to severe Atopic Dermatitis (eczema)

✔️ How Remus 0.1% 10gm works

Remus 0.1% 10gm is an immunosuppressant. It works by suppressing the activity of certain immune cells that cause inflammation (redness and swelling) of the skin. This relieves itching and improves rashes in atopic dermatitis.

✔️ How to use Remus 0.1% Ointment 10gm

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and gently massage the ointment.

✔️ What if you forget to take Remus 0.1% 10gm?

If you miss a dose of Remus 0.1% 10gm, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

✔️ Side Effects of Remus 0.1% Ointment

• Itching
• Burning sensation
• Redness
• Pain
• Skin tingling

✔️ Quick Suggestions:

• Remus 0.1% 10gm is effective at treating eczema (atopic dermatitis) when other treatment options have failed.
• It works by decreasing itching, redness, and skin rashes.
• Apply thinly, to affected areas of skin only. Clean the affected area and dry well before applying Remus 0.1% 10gm. Avoid contact with water after application.
• Inform your doctor if there's no improvement even after two weeks of treatment, or if the skin gets worse.
• Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
• Stop using Remus 0.1% 10gm and consult your doctor if your eczema becomes infected.
• Avoid contact of your skin with harsh soaps, detergents, cleaning supplies, dust or sand, wool, synthetic fibers, and cigarette smoke.
• Continuous long-term use of the ointment should be avoided. Use as prescribed by your doctor.

✔️ Indications of Remus 0.1% Ointment

Remus 0.1% Ointment 10gm is a member of a group of medications known as "immunosuppressants," which are used to treat mild to severe atopic dermatitis. (eczema). Eczema, commonly referred to as atopic dermatitis, is a common skin ailment marked by itchy, irritated skin areas. Itchy, dry, flaky, bloated, rough, and irritated skin are among the symptoms.

Tacrolimus, an ingredient in Remus 0.1% Ointment, acts by preventing immune cells in the skin from overreacting to stimuli. As a result, it lessens inflammation and allergic responses. (redness and swelling). 

✔️ Pharmacology

Tacrolimus is a macrolide immunomodulator produced by Streptomyces tsukubaensis. Tacrolimus has been shown to inhibit T-cell activation by binding to an intracellular protein known as FKBP-12. Tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin form a complex that inhibits the phosphatase activity of calcineurin. As a result, the entire inflammatory cascade is suppressed.

✔️ Dosage & Administration

• Adults should apply a thin layer of Tacrolimus ointment to the affected skin areas twice daily and gently rub it in.
• Treatment should be continued for one week after the signs and symptoms of atopic dermatitis have resolved.
• Tacrolimus ointment has not been evaluated for safety under occlusion, which may promote systemic exposure.
• Tacrolimus ointment should never be used in conjunction with occlusive dressings.

Use in Children:

• Pediatric patients 2 years of age and older can use Tacrolimus 0.03% ointment.
• Tacrolimus 0.1% ointment is appropriate for children aged 16 and up.
• Tacrolimus ointment was given to patients over the age of 65 in phase 3 studies. These patients' adverse event profile was consistent with that of other adult patients.

✔️ Interaction

Tacrolimus ointment has not been the subject of any formal topical medication interaction studies. Concurrent administration of known CYP3A4 inhibitors should be done with caution in patients with extensive and/or erythrodermic illnesses. Such medications include erythromycin, itraconazole, ketoconazole, fluconazole, calcium channel blockers, and cimetidine.

✔️ Contraindications

Patients having a history of hypersensitivity to Tacrolimus or any other component of the product should not use Tacrolimus ointment.

✔️ Pregnancy & Lactation

Pregnancy Classification C. There have been no good and well-controlled studies of Tacrolimus used topically in pregnant women. Although systemic absorption of Tacrolimus after topical application is modest compared to systemic dosing, it is known that Tacrolimus is eliminated in human milk. Because of the risk of major Tacrolimus side effects in nursing infants, a decision should be made whether to stop breastfeeding or stop taking the drug, taking into account the drug's importance to the mother.

✔️ Precautions & Warnings

• Tacrolimus ointment should be used with caution in patients with atopic dermatitis who are prone to superficial skin infections.
• Tacrolimus ointment has not been shown to be safe in patients with generalized erythroderma.

✔️ Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.